Clues in the Blood: Solving the Mystery of Cancer of Unknown Origin

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Imagine a detective who finds clear clues at a crime scene but has no idea where the crime actually took place. Medicine faces this exact mystery: patients can actually be diagnosed with a specific condition called Cancer of Unknown Primary (CUP)—when standard procedures like medical imaging and tissue biopsies fail to identify where a tumor started. Far more common and aggressive than most people realize, CUP accounts...